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Health

Medicine dose by body weight

Milligrams per dose and per day, millilitres of syrup or number of tablets from a dose prescribed in mg/kg.

kg

Actual weight, measured on scales if possible. Any weight error carries straight into the dose.

mg/kg

From the leaflet or the prescription, in milligrams per kilogram. Make sure it is not in micrograms (µg) or grams.

For example, every 8 hours = 3 doses; every 6 hours = 4 doses.

mg/mL

Milligrams per millilitre. If the bottle says “250 mg/5 mL”, that is 50 mg/mL.

mg/d

The leaflet's maximum for this patient. If the calculated dose exceeds it, the dose capped at the maximum is also shown.

Result

Dose per administration
mg
Volume per dose
mL
Tablets per dose
Daily dose
mg/d
Daily dose capped at maximum
mg/d
Dose per administration capped at maximum
mg
Volume per dose capped at maximum
mL
Tablets per dose capped at maximum

How it is calculated

Dose per administration (mg) = weight (kg) × dose (mg/kg). If the prescribed dose is per day, divide it: dose per administration = weight × dose (mg/kg/day) ÷ doses per day. Daily dose = dose per administration × doses per day.

Volume per dose (mL) = dose per administration (mg) ÷ concentration (mg/mL). Tablets per dose = dose per administration (mg) ÷ mg per tablet.

If there is a maximum daily dose and the daily dose exceeds it, the capped dose per administration = maximum daily dose ÷ doses per day.

Worked example: child of 20 kg, 10 mg/kg per dose, 3 doses a day, syrup at 20 mg/mL. Dose per administration = 20 × 10 = 200 mg; daily dose = 200 × 3 = 600 mg; volume per dose = 200 ÷ 20 = 10 mL.

Example with a maximum: adult of 70 kg, 15 mg/kg/day in 3 doses, maximum 1000 mg/day. Daily dose = 70 × 15 = 1050 mg, which exceeds 1000 mg; the capped dose is 1000 ÷ 3 = 333.3 mg per dose.

Keep in mind

  • Support calculation: it does not replace the package leaflet or the judgement of a doctor or pharmacist. Always double-check the dose before giving it.
  • The most serious error is units: 1 g = 1000 mg and 1 mg = 1000 µg (micrograms). Also check whether the concentration is per mL or per 5 mL.
  • Measure liquids with an oral syringe or dosing cup, never with kitchen spoons.
  • Only split scored tablets, and at most in half. Capsules and modified-release or enteric-coated tablets must not be split.
  • In children the per-kilogram dose must not exceed the adult dose. In newborns, the elderly, pregnancy, obesity and kidney or liver failure doses are often different: check the leaflet or ask a professional.

See also